APP Monoclonal Antibody - BT-MCA2109

APP Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2109-50, BT-MCA2109-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Research Areas: Neuroscience, Signal Transduction

Target Protein: APP

Applications: ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3F12F6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: APP

Immunogen: Purified recombinant fragment of human APP (AA: 483-699) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide.

Molecular Weight (Da): 87kDa

UniProt Accession: P05067

Synonyms: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma

GeneID: 351

Research Use Only