Product Description

AR Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2425-50, BT-MCA2425-100

Citations, Manuals and MSDS Available upon request.

Background: AR: androgen receptor. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Research Areas: Signal Transduction

Target Protein: AR

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1A9D12

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: AR

Immunogen: Purified recombinant fragment of AR (aa689-919) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P10275

Synonyms: KD, AIS, TFM, DHTR, SBMA

GeneID: 367

Research Use Only