Product Description

ARC Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11228-50, ES11228-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.,similarity:Belongs to the ARC/ARG3.1 family.,subcellular location:Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.,subunit:Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 70-150

Isotype: IgG

Target: ARC

Specificity: ARC Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Brain, Forebrain, Uterus,

Observed Band (KD): 43kD

Fields: Amphetamine addiction

Function: Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors
Similarity: Belongs to the ARC/ARG3.1 family
Subcellular Location: Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail
Subunit: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2

Subcellular Location: Extracellular vesicle membrane, Lipid-anchor Cell junction, synapse, postsynaptic cell membrane, Lipid-anchor Cell junction, synapse Cell junction, synapse, postsynaptic density Early endosome membrane Cell projection, dendrite Cytoplasm, cytoskeleton Cytoplasm, cell cortex Cell projection, dendritic spine Cytoplasmic vesicle, secretory vesicle, acrosome Forms virion-like extracellular vesicles that are released from neurons Enriched in postsynaptic density of dendritic spines Targeted to inactive synapses following interaction with CAMK2B in the kinase inactive state Accumulation at weaker synapses may be required to prevent their undesired enhancement Associated with the cell cortex of neuronal soma and dendrites (By similarity) Associated with the sperm tail (

Storage and Stability: -20°C/1 year

Gene Name: ARC KIAA0278

Protein Name: Activity-regulated cytoskeleton-associated protein (ARC/ARG3.1) (Activity-regulated gene 3.1 protein homolog) (Arg3.1)

Mouse SwissProt Number: Q9WV31

Rat SwissProt Number: Q63053

Research Use Only