Arrestin-Beta-2 Monoclonal Antibody - BT-MCA0186

Arrestin-Beta-2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0186-50, BT-MCA0186-100

Citations, Manuals and MSDS Available upon request.

Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Signal transduction

Target Protein: ARRB2

Applications: WB, IF, ICC

Reactivity: Human,Mouse,Rat,Pig

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Beta-arrestin-2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P32121; Mouse: Q91YI4; Rat: P29067

Synonyms: ARRB2; ARB2; ARR2; Beta-arrestin-2; Arrestin beta-2

GeneID: Human: 409; Mouse: 216869; Rat: 25388

Research Use Only