Product Description

ATF5 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS77606-50, BS77606-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transcription factor that either stimμlates or represses gene transcription through binding of different DNA regμlatory elements such as cAMP response element (CRE (consensus: 5'-GTGACGT[AC][AG]-3', ATF5-specific response element (ARE (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3' but also the amino acid response element (AARE, present in many viral and cellμlar promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Important regμlator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regμlated in order for such cells to exit the cycle and differentiate (By similarity. Participates in the pathways by which SHH promotes cerebellar granμle neuron progenitor cells proliferation (By similarity. Critical for survival of mature olfactory sensory neurons (OSN, directs expression of OSN-specific genes (By similarity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF/ICC

Alternate Names: ATFX, HMFN0395, ATF5

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human ATF5(NP_036200.2).

Dilution: WB, 1:500 - 1:2000 IHC, 1:50 - 1:200 IF/ICC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 31kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y2D1

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only