Product Description

ATM (I1987) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5505-50, BS5505-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC

Alternate Names: A-T mutated, A-T mutated homolog, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT protein, AT1, AT1, ATA, Ataxia telangiectasia gene mutated in human beings, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human), Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM, DKFZp781A0353, Human phosphatidylinositol 3 kinase homolog, MGC74674, OTT

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 1957-2006 of Human ATM.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ATM (I1987) polyclonal antibody detects endogenous levels of ATM protein.

Molecular Weight: ~ 350 kDa

Pathway: Cell Cycle Control G1 S Checkpoint, Cell Cycle G2 M DNA Damage Signaling Pathway, Mitochondrial Control of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13315

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only