ATM Monoclonal Antibody - BT-MCA4322

ATM Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4322-50, BT-MCA4322-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: ATM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5C5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ATM

Immunogen: Purified recombinant fragment of human ATM expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 351kDa

UniProt Accession: Q13315

Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, ATM

GeneID: 472

Research Use Only