ATP-citrate synthase Monoclonal Antibody - BT-MCA0196

ATP-citrate synthase Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0196-50, BT-MCA0196-100

Citations, Manuals and MSDS Available upon request.

Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Research Areas: Signal transduction; Metabolism; Cancer

Target Protein: ACLY

Applications: WB, IF, ICC, FCM

Reactivity: Human,Mouse,Rat,Bovine,Chicken,Pig,sheep

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: ATP-citrate synthase

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P53396; Mouse: Q91V92; Rat: P16638

Synonyms: ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme

GeneID: Human: 47; Mouse: 104112; Rat: 24159

Research Use Only