ATS5 Polyclonal Antibody - BT-AP06602

ATS5 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06602-20, BT-AP06602-50, BT-AP06602-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.

Research Areas: Signal transduction; Cell biology

Target Protein: ADAMTS5

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: A disintegrin and metalloproteinase with thrombospondin motifs 5

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9UNA0; Mouse: Q9R001

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 5;ADAM-TS 5;ADAM-TS5;ADAMTS-5;EC 3.4.24.-;A disintegrin and metalloproteinase with thrombospondin motifs 11;ADAM-TS 11;ADAMT

GeneID: Human: 11096

Research Use Only