ATX3 Polyclonal Antibody - BT-AP06605

ATX3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06605-20, BT-AP06605-50, BT-AP06605-100

Citations, Manuals and MSDS Available upon request.

Background: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Areas: Epigenetics and nuclear signaling; Neuroscience

Target Protein: ATXN3

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Ataxin-3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P54252; Mouse: Q9CVD2; Rat: O35815

Synonyms: Ataxin-3;EC 3.4.19.12;Machado-Joseph disease protein 1;Spinocerebellar ataxia type 3 protein

GeneID: Human: 4287

Research Use Only