AURKB Monoclonal Antibody - BT-MCA3714

AURKB Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3714-50, BT-MCA3714-100

Citations, Manuals and MSDS Available upon request.

Background: AURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis.It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases

Research Areas: Cell Biology

Target Protein: AURKB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 13E8D3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: AURKB

Immunogen: Purified recombinant fragment of AURKB expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q96GD4

Synonyms: AURKB

GeneID: 9212

Research Use Only