Product Description

Aurora A Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66513-50, MB66513-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Aurora A (AIK) is a cell cycle-regμlated Ser/Thr protein kinase that is overexpressed in many tumor cell lines . Phosphorylation of Aurora A at Thr288 within the kinase activation loop resμlts in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis . The closely-related kinase Aurora B (AIM1) has been implicated in mμltiple mitotic events , and siRNA silencing of Aurora B expression resμlts in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization.

Category: Primary Antibody

Reactivity: Human, Monkey

Host: Mouse

Applications: WB, IF/ICC

Alternate Names: AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6, Aurora kinase A, Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human Aurora Kinase A protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000), IF/ICC (1/50 - 1/100)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Aurora A protein.

Molecular Weight: ~ 48 kDa

Pathway: Immune checkpoint signaling in the Tumor Microenvironment

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14965

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only