Product Description

B2MG Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11333-50, ES11333-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 40-120

Isotype: IgG

Target: B2MG

Specificity: B2MG Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Dendritic cell, Eye, Leukemia, Peripheral blood, Skin, Trachea, Urine,

Observed Band (KD): 13kD

Fields: Antigen processing and presentation, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection

Function: Disease: Defects in B2M are the cause of hypercatabolic hypoproteinemia [MIM: 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation
Function: Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules
Online Information: Beta-2-microglobulin entry,PTM: Glycation of Ile-21 is observed in long-term hemodialysis patients
Similarity: Belongs to the beta-2-microglobulin family
Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

Subcellular Location: Secreted Cell surface Detected in serum and urine (PubMed:1336137, PubMed:7554280), (Microbial infection) In the presence of Mtuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553)

Storage and Stability: -20°C/1 year

Gene Name: B2M CDABP0092 HDCMA22P

Protein Name: Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

Mouse SwissProt Number: P01887

Rat SwissProt Number: P07151

Research Use Only