BAG3 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A14826-20, A14826-100
Citations, Manuals and MSDS Available upon request.
Background: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 62kDa
Observed Molecular Weight: 80kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 9531
SWISS: O95817
Alternate Names: BIS; MFM6; BAG-3; CAIR-1; BAG3
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 IHC-P, 1:50 - 1:100 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Invasion and Metastasis, Cell Biology Developmental Biology, Apoptosis, Endocrine Metabolism.
NCBI Alias: BAG3
Research Use Only