Product Description

BAMBI Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES10956-50, ES10956-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: BMP and activin membrane bound inhibitor(BAMBI) Homo sapiens This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein

Isotype: IgG

Target: BAMBI

Specificity: BAMBI Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: High expression in kidney medulla, placenta and spleen, low in kidney cortex, liver, prostate and gut, Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested,

Observed Band (KD): 28kD

Fields: Wnt signaling pathway, TGF-beta signaling pathway

Function: Developmental Stage: Expression in poorly metastatic human melanoma cell lines, no expression in highly metastatic human melanoma cell lines
Function: Negatively regulates TGF-beta signaling
Similarity: Belongs to the BAMBI family
Tissue Specificity: High expression in kidney medulla, placenta and spleen, low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested

Subcellular Location: Membrane, Single-pass type I membrane protein

Storage and Stability: -20°C/1 year

Gene Name: BAMBI NMA

Protein Name: BMP and activin membrane-bound inhibitor homolog (Non-metastatic gene A protein) (Putative transmembrane protein NMA)

Mouse SwissProt Number: Q9D0L6

Rat SwissProt Number: Q91XN4

Research Use Only