BAX Monoclonal Antibody - BT-MCA4080

BAX Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4080-50, BT-MCA4080-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]

Research Areas: Cell Biology

Target Protein: BAX

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 6H8E11

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: BAX

Immunogen: Purified recombinant fragment of human BAX(AA: (13-160)) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 21.2kDa

UniProt Accession: Q07812

Synonyms: BCL2L4

GeneID: 581

Research Use Only