Product Description

Bax (Phospho-Ser184) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65142-50, BS65142-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by BAX (BCL2 associated X, apoptosis regμlator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regμlators that are involved in a wide variety of cellμlar activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regμlated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Mμltiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC-p, IF(paraffin, section), ELISA

Alternate Names: BAX, BCL2L4, Apoptosis regμlator BAX, Bcl-2-like protein 4, Bcl2-L-4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: The antiserum was produced against synthesized peptide derived from human Bax around the phosphorylation site of Ser184. AA range:143-192

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: Phospho-Bax (S184) Polyclonal Antibody detects endogenous levels of Bax protein only when phosphorylated at S184.

Molecular Weight: /

Pathway: Regμlation of Apoptosis, SAPK JNK Signaling Cascades,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q07812

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only