BCL10 Monoclonal Antibody - BT-MCA3408

BCL10 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3408-50, BT-MCA3408-100

Citations, Manuals and MSDS Available upon request.

Background: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Research Areas: Cell Biology

Target Protein: BCL10

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3C11F4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: BCL10

Immunogen: Purified recombinant fragment of human BCL10 (AA: 98-234) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 26.3kDa

UniProt Accession: O95999

Synonyms: CLAP, mE10, CIPER, IMD37, c-E10, CARMEN

GeneID: 8915

Research Use Only