Product Description

BCLX Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67081-50, MB67081-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regμlate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regμlator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regμlates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimμlation, increases ATP availability from mitochondria through regμlation of mitochondrial membrane ATP synthase F1F0 activity and regμlates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimμlation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB

Alternate Names: BCL2L, BCLX, Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regμlator Bcl-X

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human BCLX. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of BCLX protein.

Molecular Weight: ~ 30 kDa

Pathway: Regμlation of Apoptosis，Inhibition of Apoptosis，Mitochondrial Control of Apoptosis

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q07817

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only