Product Description

Beta-catenin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66970-50, MB66970-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: β-catenin is a key downstream effector in the Wnt signaling pathway . It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis . CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β . GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 . Mutations at these sites resμlt in the stabilization of β-catenin protein levels and have been found in many tumor cell lines .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB, IF/ICC

Alternate Names: CTNNB, Catenin beta-1, Beta-catenin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-catenin. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000), IF/ICC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Beta-catenin protein.

Molecular Weight: ~ 92 kDa

Pathway: Adherens Junction signaling, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Wntβ catenin signaling.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35222

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only