Beta-Catenin Polyclonal Antibody - BT-AP09791

Beta-Catenin Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP09791-20, BT-AP09791-50, BT-AP09791-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by CTNNB1 (catenin beta 1) is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.

Research Areas: Signal Transduction

Target Protein: CTNNB1

Applications: WB

Reactivity: Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: beta-Catenin Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 85497

UniProt Accession: Human: P35222; Mouse: Q02248; Rat: Q9WU82

Synonyms: CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin

GeneID: Human: 1499; Mouse: 12387; Rat: 84353

Research Use Only