Product Description

Beta-catenin Rabbit Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66283-50, MB66283-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: β-catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites resμlt in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Hamster

Host: Rabbit

Applications: WB, IHC, IP

Alternate Names: CTNNB, Catenin beta-1, Beta-catenin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human beta Catenin

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/100), IP (1/10 - 1/50)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Beta-catenin protein.

Molecular Weight: ~ 90 kDa

Pathway: Adherens Junction signaling, ESC Pluripotency and Differentiation Signaling Pathway, ErbB HER Signaling, Wntβ catenin signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35222

Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.

Research Use Only