BLK Monoclonal Antibody - BT-MCA4122

BLK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4122-50, BT-MCA4122-100

Citations, Manuals and MSDS Available upon request.

Background: BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

Research Areas: Cell Biology

Target Protein: BLK

Applications: WB, IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 9D10B7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: BLK

Immunogen: Purified recombinant fragment of BLK expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P51451

Synonyms: MGC10442

GeneID: 640

Research Use Only