BLNK Monoclonal Antibody - BT-MCA3392

BLNK Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3392-50, BT-MCA3392-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Immunology

Target Protein: BLNK

Applications: WB, IHC, ICC, FCM

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 5G9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: BLNK

Immunogen: Purified recombinant fragment of human BLNK expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 68kDa

UniProt Accession: Q8WV28

Synonyms: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051

GeneID: 29760

Research Use Only