BMI1 Monoclonal Antibody - BT-MCA2235

BMI1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2235-50, BT-MCA2235-100

Citations, Manuals and MSDS Available upon request.

Background: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Research Areas: Epigenetics and nuclear signaling, Cancer, Cell biology, Stem cells

Target Protein: BMI1

Applications: IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3E3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: BMI1

Immunogen: Purified recombinant fragment of human BMI1 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 37kDa

UniProt Accession: P35226

Synonyms: PCGF4, RNF51, MGC12685, FLVI2/BMI1

GeneID: 648

Research Use Only