BRAF Monoclonal Antibody - BT-MCA4697

BRAF Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4697-50, BT-MCA4697-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

Research Areas: Cell Biology

Target Protein: BRAF

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 2A10D7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: BRAF

Immunogen: Purified recombinant fragment of human BRAF (AA: 299-447) expressed in HEK293-6e.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 84.4kda

UniProt Accession: P15056

Synonyms: NS7, B-raf, BRAF1, RAFB1, B-RAF1

GeneID: 673

Research Use Only