Product Description

BRCA1 (phospho-S1423) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4756-50, BS4756-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large mμlti-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modμlating the subcellμlar localization and physiological function of this gene.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Breast cancer type 1 susceptibility protein, RING finger protein 53, BRCA1, RNF53

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Serine 1423.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-BRCA1 (S1423) polyclonal antibody detects endogenous levels of BRCA1 protein only when phosphorylated at Ser1423.

Molecular Weight: ~ 200 kDa

Pathway: Cell Cycle G2 M DNA Damage Signaling Pathway,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P38398

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only