Product Description

BRCC3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS78970-50, BS78970-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumμlation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regμlates the abundance of these polyubiquitin chains in chromatin. The loss of this gene resμlts in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascμlar angiopathy. Alternative splicing resμlts in mμltiple transcript variants. A related pseudogene has been identified on chromosome 5.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: BRCC3, BRCC36, C6.1A, CXorf53

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human BRCC3(NP_077308.1).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 33kDa/36kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P46736

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only