Product Description

c-Myc Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66759-50, MB66759-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region, provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibits appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad 1 and Mxi1, and Mad 1-Max dimers have been shown to repress transcription through interaction with mSin3.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: BHLHE39, Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human c-Myc. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of c-Myc protein.

Molecular Weight: ~ 57 kDa

Pathway: Cell Cycle Control G1 S Checkpoin, MAPK Erk in Growth and Differentiation Pathway, Signaling Pathways Activating p38 MAP Kinase, Warburg Effect

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P01106

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only