Product Description

c-SRC Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66877-50, MB66877-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regμlation of growth and differentiation of eukaryotic cells . Src activity is regμlated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregμlates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active .

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Mouse

Applications: WB, IF/ICC

Alternate Names: SRC1, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src, p60-Src

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human c-SRC. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of c-SRC protein.

Molecular Weight: ~ 60 kDa

Pathway: Regμlation of Actin Dynamics, Adherens Junction signaling, Tumor Angiogenesis, ErbB HER Signaling, G Protein-coupled Receptors Signaling to MAPK Erk, Jak Stat: IL-6 Receptor Signaling, Inhibition of Apoptosis, Regμlation of Microtubμle Dynamics, Signaling Pathways Activating p38 MAP Kinase, Wntβ catenin signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P12931

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only