Product Description

c-Src (phospho-Y418) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4675-50, BS4675-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The major translational products of each of the eight members of the Src gene family identified to date are membrane-associated tyrosine protein kinases that lack transmembrane and external amino acid sequences, thereby distinguishing this group from the receptor class of tyrosine kinases. Members of this group include c-Src, c-Yes, Fyn, Lck, Lyn, Blk and c-Fgr. The major Src gene encoded protein, c-Src (also designated pp60Src, Src p60 and proto-oncogene tyrosine protein kinase Src) is expressed in a broad range of tissue and cell types, although the highest levels of c-Src are detected in neuronal tissues and platelets. c-Src may play a role in events associated with both neuronal differentiation and maintenance of mature neuronal cell functions.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Proto-oncogene tyrosine-protein kinase Src, 2.7.10.2, Proto-oncogene c-Src, pp60c-src, p60-Src, SRC1, SRC

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human c-Src around the phosphorylation site of Tyrosine 418. (removal of the initiator methionine)

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-c-Src (Y418) polyclonal antibody detects endogenous levels of c-Src protein when phosphorylated at Tyr418. (removal of the initiator methionine)

Molecular Weight: ~ 60 kDa

Pathway: Regμlation of Actin Dynamics, Tumor Angiogenesis, Regμlation of Microtubμle Dynamics, Inhibition of Apoptosis, G Protein-coupled Receptors Signaling to MAPK Erk,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P12931

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only