Product Description

C1orf19 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65476-50, BS65476-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: SEN15, also known as TSEN15 (tRNA-splicing endonuclease subunit Sen15) or C1orf19, is a nuclear protein that plays a role in tRNA splicing. Widely expressed with highest expression in testis and uterus, SEN15 is a non-catalytic subunit of the mμlti-protein tRNA-splicing endonuclease complex. The endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecμles with 2', 3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. As a subunit of the complex, SEN15 participates in protein expression and,μltimately, cell growth and division.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

Host: Rabbit

Applications: IHC-P

Alternate Names: Chromosome 1 open reading frame 19, Chromosome 1 open reading frame 19, isoform CRA_c, HsSen15, sen15, SEN15 homolog, SEN15_HUMAN, tRNA intron endonuclease Sen15, tRNA splicing endonuclease 15 homolog (S. cerevisiae), tRNA splicing endonuclease subunit Sen15, tRNA-intron endonuclease SEN15, tRNA-splicing endonuclease subunit SEN15, Tsen15.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human C1orf19/SEN15:51-150/171

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: C1orf19 Polyclonal Antibody detects endogenous levels of C1orf19 protein.

Molecular Weight: 17 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9H425

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only