Product Description

CaMK2 beta Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67096-50, MB67096-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CaMKII is an important member of the calcium/calmodμlin-activated protein kinase family, functioning in neural synaptic stimμlation and T cell receptor signaling. CaMKII has catalytic and regμlatory domains. Ca2+/calmodμlin binding to the CaMKII regμlatory domain relieves autoinhibition and activates the kinase (3). The activated CaMKII further autophosphorylates at Thr286 to render the kinase constitutively active. The threonine phosphorylation state of CaMKII can be regμlated through PP1/PKA. PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286. PKA (protein kinase A) prevents phospho-CaMKII (Thr286) dephosphorylation through an inhibitory effect on PP1.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB, IHC

Alternate Names: CAM2, CAMK2, CAMKB, Calcium/calmodμlin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human CaMK2 beta. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of CaMK2 beta protein.

Molecular Weight: ~ 60 kDa

Pathway: ErbB HER Signaling，G Protein-coupled Receptors Signaling to MAPK Erk，Regμlation of Microtubμle Dynamics，Mitochondrial Control of Apoptosis

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q13554

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only