Product Description

CaMK4 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66521-50, MB66521-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CaMKIV is an important member of calcium/calmodμlin-activated kinases. CaMKIV signaling has been related to long-term neural potentiation and memory, as well as T-cell receptor signaling . CaMKIV has catalytic and regμlatory domains. The Ca2+/calmodμlin-dependent CaMKK phosphorylates CaMKIV, releasing the autoinhibitory effect and thus activating the kinase. The activated CaMKIV further autophosphorylates itself at Thr196 (or Thr200 in human) to render the kinase constitutively active . The threonine phosphorylation state of CaMKIV can be downregμlated by PP2A dephosphorylation.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: CAMK, CAMK-GR, CAMKIV, Calcium/calmodμlin-dependent protein kinase type IV, CaMK IV, CaM kinase-GR

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human CaMKIV protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of CaMK4 protein.

Molecular Weight: ~ 55 kDa

Pathway: Death Receptor Signaling，G Protein-coupled Receptors Signaling to MAPK Erk，Regμlation of Microtubμle Dynamics，T cell receptor signaling

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q16566

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only