Product Description

CART Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11102-50, ES11102-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein AA range: 1-50

Isotype: IgG

Target: CART

Specificity: CART Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Hypothalamus, Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus,

Observed Band (KD): 12kD

Function: Disease: A defect in CART is associated with reduced resting energy expenditure and cosegregates with obesity phenotype
Function: Satiety factor closely associated with the actions of leptin and neuropeptide y, this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro
Induction: By leptin
Similarity: Belongs to the CART family
Tissue Specificity: Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: CARTPT CART

Protein Name: Cocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-39), CART(42-89)]

Mouse SwissProt Number: P56388

Rat SwissProt Number: P49192

Research Use Only