CASP9 Monoclonal Antibody - BT-MCA4045

CASP9 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4045-50, BT-MCA4045-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Research Areas: Cell Biology

Target Protein: CASP9

Applications: FCM

Clonality: Monoclonal

Clone ID: 5E8C8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CASP9

Immunogen: Purified recombinant fragment of human CASP9 (AA: 331-416) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 46.3kDa

UniProt Accession: P55211

Synonyms: MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6

GeneID: 842

Research Use Only