Product Description

Caspase-6 p18 (D162) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7006-50, BS7006-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellμlar apoptotic processes. Upon apoptotic stimμlation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A. The cleavage of this protein causes cell membrane malfunction, membrane blebbing and eventual cell death.

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: MCH2, CASP6, Caspase-6, Caspase 6, Caspase6

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 141-190 of Human Caspase-6.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Caspase-6 p18 (D162) polyclonal antibody detects endogenous levels of the large subunit of active caspase-6 resμlting from cleavage at Asp162 in mouse and rat (18 kDa). This antibody does not recognize other cleaved caspases.

Molecular Weight: ~ 18, 35 kDa

Pathway: Inhibition of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O08738

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only