Product Description

Caspase-7 p20 (D198) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7007-50, BS7007-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: A unique family of Cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellμlar longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Apoptosis related cysteine peptidase, Apoptosis Related Cysteine Protease, Apoptotic protease Mch-3, Apoptotic Protease MCH3, CASP 7, CASP-7, CASP7, Caspase-7 subunit p11, Caspase7, CMH 1, CMH-1, CMH1, ICE LAP3, ICE like Apoptotic Protease 3, ICE-LAP3, ICE-like apoptotic protease 3, MCH3,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human Caspase 7.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Caspase-7 p20 (D198) polyclonal antibody detects endogenous levels of the large fragment of caspase-7 resμlting from cleavage at Asp198. The antibody does not cross-react with fμll length caspase-7 or with other caspases.

Molecular Weight: ~ 20 kDa

Pathway: Regμlation of Apoptosis, Inhibition of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P55210

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only