CCND1 Monoclonal Antibody - BT-MCA2783

CCND1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2783-50, BT-MCA2783-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers.

Research Areas: Cell Biology

Target Protein: CCND1

Applications: WB, FCM

Clonality: Monoclonal

Clone ID: 2A5C9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CCND1

Immunogen: Purified recombinant fragment of human CCND1 (AA: 1-295) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 33.7kDa

UniProt Accession: P24385

Synonyms: BCL1, PRAD1, U21B31, D11S287E

GeneID: 595

Research Use Only