CCNT1 Polyclonal Antibody - BT-AP07233

CCNT1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP07233-20, BT-AP07233-50, BT-AP07233-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcrip

Research Areas: Cell biology; Epigenetics and nuclear signaling; Immunology; Microbiology

Target Protein: CCNT1

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Cyclin-T1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O60563; Mouse: Q9QWV9

Synonyms: Cyclin-T1;CycT1;Cyclin-T

GeneID: Human: 904

Research Use Only