Product Description

CD10 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4525-50, BT-MCA4525-100

Citations, Manuals and MSDS Available upon request.

Background: CD10(MME): membrane metallo-endopeptidase. This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Research Areas: Others

Target Protein: CD10

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3G9D10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD10

Immunogen: Purified recombinant fragment of CD10 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P08473

Synonyms: NEP, CALLA

GeneID: 4311

Research Use Only