Product Description

CD138 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4340-50, ES4340-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: SDC1, SDC, Syndecan-1, SYND1, CD138

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human SDC1. AA range:191-240

Isotype: IgG

Target: CD138

Specificity: CD138 Polyclonal Antibody detects endogenous levels of CD138 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Dermoid cancer, Fibroblast, Kidney, Mammary gland, Placenta,

Observed Band (KD): 34kD

Fields: ECM-receptor interaction, Cell adhesion molecules, Malaria, Proteoglycans in cancer, Fluid shear stress and atherosclerosis

Function: Function: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix
Similarity: Belongs to the syndecan proteoglycan family
Subunit: Interacts with CDCP1

Subcellular Location: Membrane, Single-pass type I membrane protein Secreted Secreted, extracellular exosome Shedding of the ectodomain produces a soluble form

Storage and Stability: -20°C/1 year

Gene Name: SDC1

Protein Name: Syndecan-1

Mouse SwissProt Number: P18828

Research Use Only