CD160 Monoclonal Antibody - BT-MCA3679

CD160 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3679-50, BT-MCA3679-100

Citations, Manuals and MSDS Available upon request.

Background: CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.

Research Areas: Immunology

Target Protein: CD160

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1D4A4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD160

Immunogen: Purified recombinant fragment of human CD160 (AA: 25-155) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 19.8kDa

UniProt Accession: O95971

Synonyms: NK1, BY55, NK28

GeneID: 11126

Research Use Only