Product Description

CD161 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: NCP0285P-50, NCP0285P-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation resμlts in specific acid sphingomyelinase/SMPD1 stimμlation with subsequent marked elevation of intracellμlar ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimμlation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1, 3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Category: Primary Antibody

Reactivity: Rat, Mouse, Human

Host: Rabbit

Applications: WB, IF

Alternate Names: Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant protein of human CD161.

Dilution: WB: 1:5000~1:10000
IF 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD161 polyclonal antibody detects endogenous levels of CD161 protein.

Molecular Weight: ~ 43 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q12918

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only