CD186 Monoclonal Antibody - BT-MCA3792

CD186 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3792-50, BT-MCA3792-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.

Research Areas: Others

Target Protein: CD186

Applications: WB, FCM

Clonality: Monoclonal

Clone ID: 2A4D10

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD186

Immunogen: Purified recombinant fragment of human CD186 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 39.3kDa

UniProt Accession: O00574

Synonyms: CXCR6, BONZO, CDw186, STRL33, TYMSTR

GeneID: 10663

Research Use Only