Product Description

CD19 (phospho-Y531) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4664-50, BS4664-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD19 is a transmembrane glycoprotein that contains two extracellμlar immunoglobμlin-like domains. CD19 is selectively expressed on the cell surface of B-lymphocytes, where it activates intracellμlar signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways. Activation of CD19 resμlts in cross-linking of the membrane protein immunoglobμlin chains and the subsequent association with Src family protein tyrosine kinases (PTK). Expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. CD19 forms functional complexes with B-lymphocyte surface proteins, including integrin β1, CD21 and CD81, which are involved in regμlating B-cell development.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human CD19 around the phosphorylation site of Tyrosine 531.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-CD19 (Y531) polyclonal antibody detects endogenous levels of CD19 protein only when phosphorylated at Tyr531.

Molecular Weight: ~ 61, 95 kDa

Pathway: B cell receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P15391

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only