CD204 Monoclonal Antibody - BT-MCA2380

CD204 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2380-50, BT-MCA2380-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Research Areas: Others

Target Protein: CD204

Applications: WB, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5B8H4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD204

Immunogen: Purified recombinant fragment of human CD204 (AA: extra 275-451) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 49.8kDa

UniProt Accession: P21757

Synonyms: MSR1, SRA, SR-A, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII

GeneID: 4481

Research Use Only