Product Description

CD240d Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4356-50, ES4356-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: RHD, Blood group Rh(D) polypeptide, RHXIII, Rh polypeptide 2, RhPII, Rhesus D antigen, CD240D

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from Blood group Rh(D) polypeptide at AA range: 161-210

Isotype: IgG

Target: CD240d

Specificity: CD240d Polyclonal Antibody detects endogenous levels of CD240d protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Restricted to tissues or cell lines expressing erythroid characters,

Observed Band (KD): 45kD

Function: Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane
Online Information: Blood group antigen gene mutation database,polymorphism: RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40 blood group antigen is a polymorphism in position 110
Similarity: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily
Tissue Specificity: Restricted to tissues or cell lines expressing erythroid characters

Subcellular Location: Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: RHD

Protein Name: Blood group Rh(D) polypeptide

Mouse Gene ID: 19746

Mouse SwissProt Number: Q8CF94

Rat Gene ID: 60414

Rat SwissProt Number: O88298

Research Use Only