CD243 Monoclonal Antibody - BT-MCA4216

CD243 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4216-50, BT-MCA4216-100

Citations, Manuals and MSDS Available upon request.

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

Research Areas: Others

Target Protein: CD243

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 4G6F4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CD243

Immunogen: Purified recombinant fragment of human CD243 (AA: 1149-1280) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 141.1kDa

UniProt Accession: P08183

Synonyms: ABCB1, CLCS, MDR1, P-GP, PGY1, ABC20, GP170

GeneID: 5243

Research Use Only