CD274 Monoclonal Antibody - BT-MCA2951

CD274 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2951-50, BT-MCA2951-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Research Areas: Cancer, Immunology, Signal transduction

Target Protein: CD274

Applications: IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6D9A2

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: CD274

Immunogen: Purified recombinant fragment of human CD274 (AA: 24-153) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 33.3kDa

UniProt Accession: Q9NZQ7

Synonyms: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1

GeneID: 29126

Research Use Only